Controlled Mineralization with Protein-Functionalized Peptoid Nanotubesmics of Proteins on Surfaces
October 25, 2022
Conceptual illustration (top) and outcomes (bottom) of the biomimetic mineralization process.
Developed a modular approach to controlling biomimetic mineralization and fabricating functional nanocomposites on peptoid scaffolds derivatized with solid-binding proteins.
Significance and Impact
Results show that both repetitive display and conformational flexibility of inorganic-binding segments are important in regulating mineralization and creating hierarchical materials.
Used thiol-maleimide chemistry to conjugate proteins engineered to present one or more materials-specific solid-binding peptides to self-assembled peptoid nanotubes.
Showed that protein occupancy and solid-binding peptide sequence and valency systematically regulate the size of mineralized anatase nanocrystals in the 1.4 to 4.4 nm range through modulation of particle capping efficiency.
Extended the concept of Au mineralization and to the successive mineralization of TiO₂ and Au to produce nanotubes that are photocatalytically active under visible light illumination.